KMID : 1035320210480020071
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Korean Society for Dental Materials 2021 Volume.48 No. 2 p.71 ~ p.78
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Inhibitory effect of mangosteen peel and propolis ethanol extracts on alveolar bone loss against increased treatment amount of Porphyromonas gingivalis lipopolysaccharide in rat
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Lee Kyung-Hyun
Yoo So-Young Kook Joong-Ki Sung Se-Jin Lee Ki-Won Lim Yun-Kyong Lee Dae-Sung Yu Sang-Joun
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Abstract
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In previous studies, we introduced that mangosteen extract complex (MEC; ethanol extracts of Garcinia mangostana L. peel and propolis) had inhibitory effects on inflammation and alveolar bone loss in silk-ligature applied and Porphyromonas gingivalis lipopolysaccharide (LPS) induced periodontitis model in rats. This study was conducted to evaluate whether MEC had inhibitory effect of alveolar bone loss when a higher inflammatory state was induced by increasing the injection amount of P. gingivalis LPS by 20 times and increasing the treatment dose of MEC by twice the amount or maintaining MEC dose that used in the previous study. The data showed that alveolar bone loss was significantly reduced in the Lig+L+MEC 1:34 group (treated with mixture of 16 ¥ìg mangosteen peel extract powder and 544 ¥ìg propolis extract powder) and in the Lig+L+MEC 2:68 group (treated with mixture of 32 ¥ìg mangosteen peel extract powder and 1,088 ¥ìg propolis extract powder) by 24.3% and 28.9%, respectively. This result reveals that the mixture of MEC 1:34 could be useful in improving periodontal tissue health and may be able to be used as a therapeutic adjuvant for periodontitis.
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KEYWORD
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Alveolar bone loss, Garcinia mangostana L., Propolis, Periodontitis
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